GS15083
Protein
Uniprot ID:P10820 (21-554aa)
PRF1, PFN1, PRO1, At2g19760, F6F22.21
E.coli
Mus musculus (house mouse)
N-terminal Sumo-tagged;N-terminal His-tagged;
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-141℃.
For research use only
該蛋白在分泌顆粒依賴性細(xì)胞死亡和防御病毒感染或腫瘤細(xì)胞中起關(guān)鍵作用。在殺死其他被免疫系統(tǒng)識(shí)別為非自身的細(xì)胞中起重要作用,例如在移植排斥反應(yīng)或某些形式的自身免疫性疾病中。能以鈣結(jié)合形式插入靶細(xì)胞膜,寡聚并形成大孔。通過(guò)促進(jìn)細(xì)胞毒性顆粒酶的攝取促進(jìn)靶細(xì)胞的細(xì)胞溶解和凋亡。