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Recombinant Human TSLP 貨號:300-62 細胞因子

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Recombinant Human TSLP 貨號:300-62 細胞因子
細胞因子(cytokine,CK)是一類能在細胞間傳遞信息、具有免疫調(diào)節(jié)和效應(yīng)功能的蛋白質(zhì)或小分子多肽。
作用特點:多效性、重疊性、協(xié)同性、拮抗性和雙重性。

詳細介紹

Recombinant Human TSLP 貨號:300-62 細胞因子

 

胞因子受體存在著可溶性形式,掌握可溶性細胞因子受體產(chǎn)生的規(guī)律及其生理和病理意義,必將擴展人們對細胞因子網(wǎng)絡(luò)作用的認識。檢測細胞因子及其受體的水平已成為基礎(chǔ)和臨床免疫學(xué)研究中的一個重要的方面。Catalog Number:

 
Catalog Number:
300-62
Synonyms:
Thymic Stromal Lymphopoietin
Description:
TSLP is a hemopoietic protein that is expressed in the heart, liver and prostate. TSLP overlaps biological activities with IL-7 and binds with the heterodimeric receptor complex consisting of the IL-7R α chain (IL-7Rα) and the TSLP-specific chain (TSLPR). Like IL-7, TSLP induces phosphorylation of STAT3 and STAT5, but uses kinases other than the JAKs for activation. TSLP prohibited apoptosis and stimulated growth of the human acute myeloid leukemia (AML)-derived cell line MUTZ3. It induces the release of T cell-attracting chemokines TARC and MDC from monocytes and activates CD11c(+) dendritic cells (DCs). TSLP activated DCs primed naïve T cells to produce the proallergic cytokines (IL-4, IL-5, IL-13, TNFα) while down-regulating IL-10 and IFN-γ suggesting a role in initiating allergic inflammation. Recombinant human TSLP is a 15.0 kDa protein consisting of 132 amino acid residues.
AA Sequence:
MYDFTNCDFE KIKAAYLSTI SKDLITYMSG TKSTEFNNTV SCSNRPHCLT EIQSLTFNPT AGCASLAKEM FAMKTKAALA IWCPGYSETQ INATQAMKKR RKRKVTTNKC LEQVSQLQGL WRRFNRPLLK
Source:
E.coli
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
Data not available at this time.
 
 
 
 
Cross Reactivity:
Mouse, Human
Research Interests:
Apoptosis Apoptosis Inflammation Inflammation
 
 
Country of Origin:
USA


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