行業(yè)產(chǎn)品

  • 行業(yè)產(chǎn)品

北京方程嘉鴻科技有限公司


當(dāng)前位置：北京方程嘉鴻科技有限公司>>細(xì)胞因子>>Recombinant Human NOGGIN貨號(hào):120-10細(xì)胞因子

Recombinant Human NOGGIN貨號(hào):120-10細(xì)胞因子

返回列表頁(yè)
參  考  價(jià)面議
具體成交價(jià)以合同協(xié)議為準(zhǔn)

產(chǎn)品型號(hào)

品       牌

廠商性質(zhì)生產(chǎn)商

所  在  地北京市

聯(lián)系方式：王杰查看聯(lián)系方式

更新時(shí)間：2016-06-02 01:34:32瀏覽次數(shù)：1782次

聯(lián)系我時(shí)，請(qǐng)告知來(lái)自 制藥網(wǎng)

產(chǎn)品簡(jiǎn)介

Recombinant Human NOGGIN貨號(hào):120-10細(xì)胞因子
細(xì)胞因子(cytokine,CK)是一類能在細(xì)胞間傳遞信息、具有免疫調(diào)節(jié)和效應(yīng)功能的蛋白質(zhì)或小分子多肽。
作用特點(diǎn)：多效性、重疊性、協(xié)同性、拮抗性和雙重性。

詳細(xì)介紹

Recombinant Human NOGGIN貨號(hào):120-10細(xì)胞因子

 

胞因子受體存在著可溶性形式，掌握可溶性細(xì)胞因子受體產(chǎn)生的規(guī)律及其生理和病理意義，必將擴(kuò)展人們對(duì)細(xì)胞因子網(wǎng)絡(luò)作用的認(rèn)識(shí)。檢測(cè)細(xì)胞因子及其受體的水平已成為基礎(chǔ)和臨床免疫學(xué)研究中的一個(gè)重要的方面。Catalog Number:

 
Catalog Number:
120-10C
Description:
Noggin belongs to a group of diffusible proteins which bind to ligands of the TGF-β family and regulate their activity by inhibiting their access to signaling receptors. The interplay between TGF-β ligands and their natural antagonists has major biological significance during development processes, in which cellular response can vary considerably depending upon the local concentration of the signaling molecule. Noggin was originally identified as a BMP-4 antagonist whose action is critical for proper formation of the head and other dorsal structures. Consequently, Noggin has been shown to modulate the activities of other BMPs including BMP-2,-7,-13, and -14. Targeted deletion of Noggin in mice results in prenatal death and recessive phenotype displaying a severely malformed skeletal system. Conversely, transgenic mice over-expressing Noggin in mature osteoblasts display impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis. Recombinant human Noggin is a 46 kDa disulfide-linked homodimer （120-10C） consisting of two 206 amino acid polypeptide chains. Monomeric glycosylated Noggin migrates at an apparent molecular weight of approximay 28.0-33.0 kDa by SDS PAGE analysis under reducing conditions.
AA Sequence:
QHYLHIRPAP SDNLPLVDLI EHPDPIFDPK EKDLNETLLR SLLGGHYDPG FMATSPPEDR PGGGGGAAGG AEDLAELDQL LRQRPSGAMP SEIKGLEFSE GLAQGKKQRL SKKLRRKLQM WLWSQTFCPV LYAWNDLGSR FWPRYVKVGS CFSKRSCSVP EGMVCKPSKS VHLTVLRWRC QRRGGQRCGW IPIQYPIISE CKCSC
Source:
HEK293 cells
Purity:
Greater than 95% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
Determined by its ability to inhibit 5.0 ng/ml of BMP-4 induced alkaline phosphatase production by ATDC chondrogenic cells. The expected ED50 for this effect is 2.0-3.0 ng/ml of Noggin.
 
 
 
 
Cross Reactivity:
Chicken, Mouse, Human
Research Interests:
Bone, Skeletal, Cartilage Bone, Skeletal, Cartilage Stem Cells & Differentiation Stem Cells & Differentiation
 
 
Country of Origin:
USA


您感興趣的產(chǎn)品PRODUCTS YOU ARE INTERESTED IN

制藥網(wǎng) 設(shè)計(jì)制作，未經(jīng)允許翻錄必究 .? ? ? Copyright(C)?2021 http://xingweiyishu.cn,All rights reserved.

以上信息由企業(yè)自行提供，信息內(nèi)容的真實(shí)性、準(zhǔn)確性和合法性由相關(guān)企業(yè)負(fù)責(zé)，制藥網(wǎng)對(duì)此不承擔(dān)任何保證責(zé)任。 溫馨提示：為規(guī)避購(gòu)買風(fēng)險(xiǎn)，建議您在購(gòu)買產(chǎn)品前務(wù)必確認(rèn)供應(yīng)商資質(zhì)及產(chǎn)品質(zhì)量。

會(huì)員登錄

×

請(qǐng)輸入賬號(hào)

請(qǐng)輸入密碼

=

請(qǐng)輸驗(yàn)證碼

收藏該商鋪

請(qǐng) 登錄 后再收藏

提示

您的留言已提交成功！我們將在第一時(shí)間回復(fù)您~