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Recombinant Human GM-CSF 貨號(hào):300-03 細(xì)胞因子

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Recombinant Human GM-CSF 貨號(hào):300-03 細(xì)胞因子
細(xì)胞因子(cytokine,CK)是一類能在細(xì)胞間傳遞信息、具有免疫調(diào)節(jié)和效應(yīng)功能的蛋白質(zhì)或小分子多肽。
作用特點(diǎn)：多效性、重疊性、協(xié)同性、拮抗性和雙重性。

詳細(xì)介紹

Recombinant Human GM-CSF 貨號(hào):300-03 細(xì)胞因子 

 

細(xì)胞因子受體的結(jié)構(gòu)和分類:根據(jù)細(xì)胞因子受體cDNA序列以及受體胞膜外區(qū)氨基酸序列的同源性和結(jié)構(gòu)征，可將細(xì)胞因子受體主要分為四種類型：免疫球蛋白超家族（IGSF）、造血細(xì)胞因子受體超家族、神經(jīng)生長因子受體超家族和趨化因子受體。

 

Catalog Number:
300-03
Synonyms:
Granulocyte/Macrophage Colony-Stimulating Factor, CSF-2, MGI-1GM, pluripoietin-α
Description:
GM-CSF is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages and promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. It is produced in endothelial cells, monocytes, fibroblasts and T-lymphocytes. GM-CSF inhibits neutrophil migration and enhances the functional activity of the mature end-cells. The human and murine molecules are species-specific and exhibit no cross-species reactivity. Recombinant human GM-CSF is a 14.6 kDa globular protein consisting of 128 amino acids containing two intramolecular disulfide bonds and two potential N-linked glycosylation sites.
AA Sequence:
MAPARSPSPS TQPWEHVNAI QEARRLLNLS RDTAAEMNET VEVISEMFDL QEPTCLQTRL ELYKQGLRGS LTKLKGPLTM MASHYKQHCP PTPETSCATQ IITFESFKEN LKDFLLVIPF DCWEPVQE
Source:
E.coli
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
The ED50 as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 107 units/mg.
 
 
 
 
Cross Reactivity:
Human, Bacteria, Mouse, Leech, Pig
Research Interests:
Cancer Cancer Cell Culture Cell Culture
Inflammation Inflammation Proliferation Proliferation
Stem Cells & Differentiation Stem Cells & Differentiation Wound Healing Wound Healing
 
 
Country of Origin:
USA


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